Published Papers - Abstract 57

Schofield M, Mishra G & Dobson A. Risk of early menopause among Australian women who smoke. , 2000; : 243-246

We examined the relationship between smoking status and self-reported natural menopause among 14 200 women aged 45-49 years in the Australian Longitudinal Study on Women's Health. The sampling frame was the database of the national health insurance system. Participants were randomly selected, with over-sampling from rural and remote areas and are broadly representative of Australian women in this age group. Polychotomous logistic regression analyses were used to estimate the association between current smoking status and early menopause and peri-menopausal status after adjustment for potentially confounding factors. Smokers of 1-19 cigarettes per day were 1.48 times more likely to be peri-menopausal, and women who smoked > 20 per day were 1.74 times more likely to be peri-menopausal in comparison with never smokers. Both groups of smokers were 1.8 times more likely to report post-menopausal status than women who had never smoked. For ex-smokers, the risk for earlier onset of menopause declined rapidly after quitting. The results extend earlier evidence of a link between smoking and early menopause by estimating the effects of quitting and by controlling for a wide range of potential confounders.