Published Papers - Abstract 648

Joham A, Ranasinha S, Zoungas S, Moran L & Teede H. Gestational Diabetes and Type 2 Diabetes in Reproductive-Aged women with Polycystic Ovary Syndrome. Journal of Clinical Endocrinology and Metabolism, 2014; 99(3): E447-E452

Context: Polycystic ovary syndrome (PCOS) affects 6–21% of women. PCOS has been associated with an increased risk of dysglycaemia including gestational diabetes (GDM) and type 2 diabetes (T2DM).Objective: To assess the prevalence of dysglycaemia and the impact of obesity in young reproductive-aged women with and without PCOS in a community-based cohort.Design: Cross-sectional analysis of data from a large longitudinal study (the Australian Longitudinal Study on Women’s Health (ALSWH)).Setting: General communityParticipants: Women were randomly selected from the national health insurance database. Standardised data collection occurred at 5 survey time points (years 1996, 2000, 2003, 2006 and 2009). Data from survey 4 (2006, n=9145, 62% of original cohort aged 18 to 23 years) were examined for this study.Main outcome measures: Self-reported PCOS, GDM and T2DMResults: In women aged 28 to 33 years, PCOS prevalence was 5.8% (95% CI: 5.3%-6.4%). The prevalence of GDM (in women reporting prior pregnancy) and T2DM was 11.2% and 5.1% in women with PCOS and 3.8% and 0.3% in women without PCOS respectively (p for both<0.001). PCOS was associated with increased odds of GDM and T2DM. After adjusting for age, Body Mass Index (BMI), hypertension, smoking and demographic factors, the odds of GDM (OR 2.1, 95% CI 1.1-3.9, p=0.02) and T2DM (OR 8.8, 95% CI 3.9-20.1, p<0.001) remained increased in women reporting PCOS.Conclusions: In a large community-based cohort of reproductive-aged women, PCOS was independently associated with higher risk of GDM and T2DM, independent of BMI. Aggressive screening, prevention and management of dysglycaemia is clearly warranted in women with PCOS.

Open Access Article