|Title, Synopsis and Publications||Investigators and Collaborators|
Gastrointestinal Disorders and their subsequent impact on cardiovascular disease risk in a longitudinal sample of Australian women.
The gut microbiome has a variety of vital functions including resistance to pathogens and proper metabolic functioning. Literature has indicated that a gut dysbiosis, the state of a poorly functioning gut microbiome, has important consequences for CVD e.g. changes in bile acid metabolisms and trimethylamine N-Oxide production which can increase the development of cardiovascular disease (CVD). However, gut dysbiosis is difficult to define and identify due to high inter-person variability between healthy controls. A path forward may be to use functional gastrointestinal disorders, which represent gut dysbiotic states, as predictors of CVD risk.
Prof Deborah Loxton
A/Prof Mark McEvoy
Mr Alan Ho
Dr Elizabeth Stojanovski