Details of Publication 557 for Project A398:

Koloski N, Jones M, Wai R, Gill R, Byles J, Talley N. Impact of persistent constipation on health related quality of life and mortality in older community dwelling women. American Journal of Gastroenterology, 2013; 108(7): 1152-1158

Objectives: Very little is known about whether the reported health-related impact of constipation is worse in people who experience constipation over a long period of time vs. those with more transient symptoms. We aimed to determine the impact of persistent vs. transient constipation on health-related quality of life (QOL), depression, and mortality.Methods: We analyzed data from 5,107 women (aged 70-75 years in 1996) who answered Have you had constipation in the past 12 months? in all five surveys sent out every 3 years of the Australian Longitudinal Study on Women's Health.RESULTS:Of the 5,107 women, 20.9, 54.1, and 24.7% reported having persistent constipation on at least 4 out of 5 surveys, transient constipation reported on 1-3 surveys, or none reported over the 15-year time frame, respectively. Women who reported persistent constipation had significantly lower scores for all domains of QOL on the SF-36 except role-emotional, and had higher levels of self-reported depression, even after adjusting for number of chronic illnesses and fluid intake. Mortality rates were increased when comparing women with no reported constipation with persistently reported constipation (8.2% vs. 11%, odds ratio = 1.32, 95% confidence interval 1.0, 1.74, P = 0.05) controlling for specific chronic illnesses.Conclusions: Persistent constipation among older women is associated with poor health outcomes.