Details of Publication 648 for Project A240B:

Joham A, Ranasinha S, Zoungas S, Moran L & Teede H. Gestational Diabetes and Type 2 Diabetes in Reproductive-Aged women with Polycystic Ovary Syndrome. Journal of Clinical Endocrinology and Metabolism, 2014; 99(3): E447-E452

Context: Polycystic ovary syndrome (PCOS) affects 6–21% of women. PCOS has been associated with an increased risk of dysglycaemia including gestational diabetes (GDM) and type 2 diabetes (T2DM).Objective: To assess the prevalence of dysglycaemia and the impact of obesity in young reproductive-aged women with and without PCOS in a community-based cohort.Design: Cross-sectional analysis of data from a large longitudinal study (the Australian Longitudinal Study on Women’s Health (ALSWH)).Setting: General communityParticipants: Women were randomly selected from the national health insurance database. Standardised data collection occurred at 5 survey time points (years 1996, 2000, 2003, 2006 and 2009). Data from survey 4 (2006, n=9145, 62% of original cohort aged 18 to 23 years) were examined for this study.Main outcome measures: Self-reported PCOS, GDM and T2DMResults: In women aged 28 to 33 years, PCOS prevalence was 5.8% (95% CI: 5.3%-6.4%). The prevalence of GDM (in women reporting prior pregnancy) and T2DM was 11.2% and 5.1% in women with PCOS and 3.8% and 0.3% in women without PCOS respectively (p for both<0.001). PCOS was associated with increased odds of GDM and T2DM. After adjusting for age, Body Mass Index (BMI), hypertension, smoking and demographic factors, the odds of GDM (OR 2.1, 95% CI 1.1-3.9, p=0.02) and T2DM (OR 8.8, 95% CI 3.9-20.1, p<0.001) remained increased in women reporting PCOS.Conclusions: In a large community-based cohort of reproductive-aged women, PCOS was independently associated with higher risk of GDM and T2DM, independent of BMI. Aggressive screening, prevention and management of dysglycaemia is clearly warranted in women with PCOS.