Details of Publication 765 for Project A261A:

Harding JL, Sooriyakumaran M, Anstey K, Adams R, Balkau B, Brennan-Olsen SL, et al. The metabolic syndrome and cancer: is the metabolic syndrome useful for predicting cancer risk above and beyond its individual components? Diabetes and Metabolism, 2015; 41(6): 463-9-1 0:

Aims: The metabolic syndrome (MetS) is a risk factor for cancer. However, it is not known if the MetS confers a greater cancer risk than thesum of its individual components, which components drive the association, or if the MetS predicts future cancer risk.Materials and methods: We linked 20,648 participants from the Australian and New Zealand Diabetes and Cancer Collaboration with completedata on the MetS to national cancer registries and used Cox proportional hazards models to estimate associations of the MetS, the number ofpositive MetS components, and each of the five MetS components separately with the risk for overall, colorectal, prostate and breast cancer. Hazardratios (HR) and 95% confidence intervals (95%CI) are reported. We assessed predictive ability of the MetS using Harrell’s c-statistic.Results: The MetS was inversely associated with prostate cancer (HR 0.85; 95% CI 0.72-0.99). We found no evidence of an association betweenthe MetS overall, colorectal and breast cancers. For those with five positive MetS components the HR was 1.12 (1.02-1.48) and 2.07 (1.26-3.39) foroverall, and colorectal cancer, respectively, compared with those with zero positive MetS components. Greater waist circumference (WC) (1.38;1.13-1.70) and elevated blood pressure (1.29; 1.01-1.64) were associated with colorectal cancer. Elevated WC and triglycerides were (inversely)associated with prostate cancer. MetS models were only poor to moderate discriminators for all cancer outcomes.