Participant Information Sheet

For other states

Genes are made up of DNA – the chemical structure carrying your genetic information that determines many human characteristics, such as the colour of your eyes or hair. Researchers study genes in order to understand why some people have a certain condition, such as diabetes and asthma, and why others do not. Understanding a person’s genes may also explain why some people respond to a treatment or experience a side effect, while others do not.

Women are at greater risk of poor health than men as they age. This could be due to one or a combination of factors in a woman’s life. Therefore, the purpose of this research project is to examine how reproductive (e.g. age at menarche or first period), sociodemographic (e.g. education level, where you live), lifestyle, and genetic factors influence risk of poor health in women.

This study is being run by Professor Gita Mishra at the University of Queensland and the University of Newcastle, and has been funded by the National Health and Medical Research Council.

In your most recent survey, you indicated that you were interested in the M-PreM substudy. This study is not suitable for you if you: are pregnant, or receiving treatment for a reproductive cancer.

If you agree to take part, you can book a health check by calling Women’s Health Australia or we will call you 1-2 weeks after sending you an invitation. You will be sent an appointment confirmation by email or mail that contains instructions on what you will need to do in preparation for your appointment. The health check will take approximately 1.5 hours. It will include:

Short questionnaireYou will be asked questions about when you last had something to eat or drink, your menstrual cycle status and hormone use, respiratory symptoms, and recent use of medications and health behaviours that affect your lung function.
Blood pressure and resting heart rateUsing an automated blood pressure monitor that is commonly used in clinics and hospitals.
Blood collectionApproximately 30mL (just over 1 tablespoon) of blood will be taken from a vein in your arm to measure your levels of cardiovascular and metabolic biomarkers and sex hormones. Blood will also be collected for storage and genetic analysis (please refer to sections 10 and 13 for more information).
Handgrip strengthBy squeezing a device known as a dynamometer using each hand.
Standing balance testTiming how long you can stand on one leg with your eyes open and then with your eyes closed.
Chair rise testTiming how long it takes for you to complete 10 sitting-to-standing exercises.
Cognitive testBy completing a short questionnaire.
Body size measurementYour height, weight, and waist, hip, arm, and thigh circumference will be measured.
Physical activity monitor and sleep diaryYou will be asked to wear a small physical activity monitor (4.5cm x 2.5cm) on your thigh and complete a sleep diary for 8 days. The physical activity monitor will be attached at the end of the health check and you will be provided instructions on what to do and how to return the device at the end of the 8 days.
Menstrual cycle diaryIf you have ever been diagnosed or treated for polycystic ovary syndrome, you will be asked to complete a menstrual diary for 3 months.

Research results from this study are unlikely to be of any immediate and specific benefit to you. The data from this study will be analysed and future medical discoveries may result from your participation. This will help improve and personalise medical treatment and care for women overall. We will, however, send you the results of your cardiovascular and metabolic biomarker test, body size, blood pressure and resting heart rate, and physical activity and sleep pattern, where available. If you are concerned about any of these results, we encourage you to seek advice from your GP.

  • The side effects of having blood collected may include bleeding or bruising at the injection site and possible dizziness and/or fainting. Please advise the nurse if you normally feel dizzy or faint when you have blood collected.
  • You may feel uncomfortable with a particular measurement/test. If you do not wish to answer a question or do a test or measurement, you may skip it and go to the next part of the health assessment, or you may stop completely.
  • It may be possible to trace your genetic sequence back to you, however, this is very unlikely because your genetic data and personal information will be kept in physically separate and secure locations.
  • All personal, questionnaire and genetic information collected for the study remains confidential in accordance with the National Health and Medical Research Council (NHMRC) ethical guidelines and the Australian 1988 Privacy Act.
  • Your personal details, questionnaire data, and genetic data will all be stored separately.
  • The data you provide in this study will be linked to the questionnaire data collected by Women’s Health Australia in previous and future surveys.
  • The only link between your personal details and your other data is your participant ID number. Linking your personal details and other data using this number is restricted to authorised members of the Women’s Health Australia research team at the University of Newcastle.
  • All other questionnaire and genetic information data about you will be de-identified (i.e. will not contain identifying information, such as your name, address, and date of birth) and stored securely at the University Queensland.
  • Your information will be stored indefinitely at these two sites.
  • This information may continue to be valuable to researchers many years into the future, and may be considered for use in future projects. These projects will require approval by the relevant ethics committees before they begin.
  • Your genetic information (but not your biological sample), sleep patterns, physical activity data, and some of your questionnaire information (but not your name, address or date of birth) may eventually be put into an international data repository. Information in the repository will only be available to researchers from around the world who are approved to study how genes, sleep, or physical activity cause a variety of health conditions.
  • Your data will be combined with the data from many other women before analysis so there will be no way of identifying you as a participant. Results of this research project may be presented in scientific or public articles and talks, but your identity will not be revealed.

Your blood sample will be used to test markers of heart disease and metabolic disorders (e.g. Type 2 diabetes), and sex hormone levels. The research team will look at the differences and similarities of these blood biomarkers between participants. With the lifestyle, sociodemographic, and reproductive information, we will examine why some people are more likely to have a certain condition, such as heart disease, than others. We will also use your blood sample to extract your DNA and analyse a small number of genes which are likely to be associated with determining the age when your period starts, other reproductive characteristics, and the development of heart and metabolic diseases. The analysis of these genes cannot be used for diagnosis, but could advance knowledge about disease risk.

Because you will be asked to attend a research clinic, you will be sent a $20 gift card to cover travel costs after you have participated in the study.

You will receive results in the mail of your cardiovascular and metabolic biomarker test, blood pressure and resting heart rate, body measurements, physical activity and sleep patterns. Also, the results of the research project may be presented in scientific or public articles and talks. We will not report the study results in any way that could identify you. Only grouped and summarised results will be reported. We will not publish any information that could identify any particular person.

Your DNA and blood samples will be stored indefinitely for future research projects, as part of Women’s Health Australia in collaboration with Professor Gita Mishra that may or may not be related to this project. All future projects will require approval from the Human Research Ethics Committee with oversight of Women’s Health Australia. The blood and DNA that you provide (but not your personal details) may be made available to other researchers working with Professor Mishra to study different health conditions, some of whom may have commercial interests. If you consent to participate, you will be donating your blood freely for these purposes and waive any claim to commercial rights arising from this work. Your DNA and any remaining blood samples will be stored securely at the University of Queensland Institute for Molecular Biosciences. Your blood and DNA samples will be stored in tubes with a barcode label containing your project ID number (not the Women’s Health Australia participant number you receive on emails and letters). This means that your samples may be re-identifiable, however the likelihood of this happening is very low. You can have the samples destroyed at any time by contacting the Women’s Health Australia.

Participation in this study is voluntary. It is completely up to you whether or not you wish to participate and it will not affect your relationship with Women’s Health Australia. You can leave the study at any time without giving a reason and without consequences of any kind. If you are unable to attend the clinic, you can request a M-PreM@home package that will allow you to do the following measurements and tests by yourself:

  • Short questionnaire – regarding your menstrual cycle status and hormone use, respiratory symptoms
  • Body size measurements – as described in section 6.
  • Physical activity monitor and sleep diary – as described in section 6.
  • Menstrual diary – as described in section 6.
  • Saliva sample – you will be asked to provide 2ml of saliva, which will be used to extract DNA for genetic analysis.

You can also specifically withdraw your biological samples at any time without consequences of any kind. If you do withdraw your biological samples, you can choose to destroy all stored samples and/or unpublished data that has been obtained from using the samples. Note that data that are already deposited in an international data repository or published will not be withdrawn and destroyed.

All research in Australia involving humans is reviewed by an independent group of people called a Human Research Ethics Committee (HREC). The ethical aspects of this research project have been approved by the HREC of the University of Newcastle and the University of Queensland. This project will be carried out according to the National Statement on Ethical Conduct in Human Research (2007). This statement has been developed to protect the interests of people who agree to participate in human research studies.

If you want any further information concerning this project, you can contact Women’s Health Australia on 1800 068 081 (Freecall) or email
If you have any complains about any aspect of the project, the way it is being conducted or any questions about being a research participant in general, then you may contact the Metro South Health and Health Service Human Research Ethics Committee (EC00167) (Approval number HREC/2019/QMS/52052):

  • Contact Person: MSH HREC Coordinator
  • Phone: 07 3443 8049
  • Email:

If you are interested in participating in the M-PreM study, please contact Women’s Health Australia on 1800 068 081 (free call) or email to make a booking or to get more information.