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Dietary zinc intake, incident type-2 diabetes and depression in Australian women


The primary aim of this project was to analyse measures of dietary zinc intake and dietary zinc to iron ratio in a random community based sample of women aged 45 to 50 years and determine if low zinc intake is associated with self-report incident type-2 diabetes and incident CESD depression. The project analysis and results for the type-2 diabetes componet of the project are complete. A total of 333 incident cases of diabetes were identified over 6 years of follow-up. After adjustment for dietary and non-dietary factors, the highest quintile of dietary zinc intake had almost half the odds of developing type-2 diabetes (OR=0.55, 95% C.I. 0.36 – 0.86) compared with the lowest quintile. Similar findings were observed for the zinc/iron ratio; the highest quintile had half the odds of developing T2D (OR=0.49, 95% C.I 0.29-0.80) after multivariate adjustment of covariates. A manuscript has been prepared and is currently under review in Diabetiologia. The analysis for the depression component of the project is ongoing and this will be written as a manuscript that will be submitted to the Journal of Affective disorders.