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The role of chronic inflammation in the development and progress of arthritis and comorbidities.


Inflammation is increasingly being linked to chronic disease. This relationship is specifically with ‘low-grade’ or ‘chronic’ inflammation - sometimes called ‘metaflammation’, which is principally triggered by nutrients and metabolic surplus. Given the role of inflammation in arthritis, an examination of the relationship of overweight/ obesity, diet and other chronic disease with occurrence of arthritis within the mid aged (1946-51) ALSWH cohort may elucidate and confirm the pathways for development of this disabling chronic condition. The research questions are: Is the development of arthritis associated with development of other systemic inflammatory diseases (asthma, CVD, diabetes)? And does the onset of obesity/weight gain or dietary intake contribute to this?