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Investigating the association between depressive symptoms and hypertension in the young ALSWH cohort.


Depression might lead to an increased risk of hypertension. However, findings of published studies are conflicting and many have methodological limitations. We aim to investigate the association between time?varying depressive symptoms and hypertension among the young ALSWH cohort, to assess whether the association varies by distinct depressive symptom subgroups, and to investigate factors that might mediate this increased risk. For example, a previous study using the mid?aged ALSWH cohort found that depressive symptoms were associated with increased risk of hypertension. This association markedly attenuated following adjustment for body mass index (BMI), suggesting that BMI may confound and/or mediate the association.