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Menopausal hormone therapy use and the risk of melanoma.


The association between use of menopausal hormone therapy and risk of cutaneous melanoma is highly debated. We investigated the association in different European cohorts, showing a detrimental effect of estrogens on melanoma risk. Moreover, our findings suggest a possible protective effect of progestins. We would like to evaluate this association in the ALSWH. The present study will focus on the 1946–1951 cohort, because in that cohort we have the information on HRT use from both the questionnaires and the Pharmaceutical Benefits Scheme. Information on hysterectomy and menopausal status will be used, together with other possible confounders.