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M-PreM study: Reproductive factors, from menarche to premenopause, and the risk of cardiometabolic and respiratory conditions before menopause.


Chronic conditions and poor health show marked sex differences in their prevalence and severity across the life course. Previous studies have typically focussed on risk factors for these conditions among postmenopausal women. This study maps the pathways between female reproductive factors, from the first period through to pregnancy and subfertility, and the risks of cardiometabolic and respiratory conditions and poor health among women in their 40s. This study involves conducting a range of biomedical tests (body size measurements, cognitive test, handgrip strength, lung function), fitting a physical activity monitor, and collecting blood samples to measure cardiometabolic and hormone markers and for biobanking.