Published Papers - Abstract 511

Chiarelli P & Sibbritt D. Are women diagnosed with osteoporosis more likely to develop urinary incontinence and pelvic organ prolapse? A longitudinal analysis. Osteoporosis International, ; :

In women, urinary incontinence and osteoporosis are prevalent, progressive disorders. Osteoporosis is characterised by compromised bone strength resulting in vertebral fractures, the most prevalent female osteoporotic fractures. Such fractures are strongly correlated with spinal deformity, and height loss - hypothesised to increase intraabdominal pressure. Height loss inherent with osteoporosis is significantly associated with female urinary incontinence which is associated with pelvic organ prolapse. This study aimed to longitudinally explore associations between diagnosis of osteoporosis in relation to onset of urinary incontinence and pelvic organ prolapse surgery in Australian women.Method: Responses were analysed from 10,951 mid-aged women (aged 45-50 years in 1966) across 5 surveys and 8847 elderly women (aged 70–75 in 1996) across 4 surveys in the Australian Longitudinal Study on Women's Health. After adjusting for confounders, crude and adjusted odds ratios for osteoporosis were obtained using longitudinal generalized estimating equation models, predicting pelvic organ prolapsed and incontinence for both cohorts. Results: Statistically significant associations were found between osteoporosis and urinary incontinence (OR=1.21; 95% CI: 1.11, 1.33) and pelvic organ prolapse (OR=1.44; 95% CI: 1.27, 1.64) in both the mid-age and older women. However, a statistically significant association was only found between osteoporosis and pelvic organ prolapse (OR=1.46; 95% CI: 1.13, 1.89) in mid-age women.Conclusion: Mid-aged and older women diagnosed with osteoporosis are at increased risk of developing urinary incontinence and pelvic organ prolapse suggesting that on diagnosis of osteoporosis, women be screened for and informed about their increased risk of developing urinary incontinence and pelvic organ prolapse.