Details of Publication 595 for Project A386:

Herber-Gast GC, Mishra G, van der Schouw Y, Brown W & Dobson A. Risk factors for night sweats and hot flushes in midlife: results from a prospective cohort study. Menopause, 2013; 20(9): 953-959

Objective: To identify social, lifestyle, and reproductive history risk factors of night sweats (NS) only, hot flushes (HF) only and co-occurrence of both NS and HF. Methods: Risk factors and symptoms were measured at baseline and at three-year intervals (survey 2-6) over 15 years, in 10,454 participants in the Australian Longitudinal Study on Women’s Health who were aged 45-50 years at baseline in 1996. Multinomial logistic regression analyses were performed. Results: Compared to neither symptom, both symptoms together were reported less often by highly educated women (Odds Ratio:0.61 [99.9% Confidence Interval:0.50-0.74]), but more often by women who were heavier (1.23 [1.08-1.40]), current smokers (1.31 [1.09-1.56]), risky drinkers (1.44 [1.10-1.89]) peri- (6.57 [5.52-7.82]) or postmenopausal (4.74 [4.00-5.63]) and had gained weight (1.15 [1.01,1.31]) or had premenstrual tension (1.86 [1.48-2.34]) than by women without these characteristics. HF only was reported less often by highly educated women (0.73 [0.59- 0.90]), but more often by peri-menopausal (3.58 [2.95-4.35]) or postmenopausal (2.97 [2.47-3.57]) women and by those with premenstrual tension (1.60 [1.25-2.04]). Finally, NS only was reported more often among current smokers (1.55 [1.11-2.19]), risky drinkers (1.76 [1.04-2.97]), peri-menopausal women (1.53 [1.14-2.06]) and by those with diabetes (1.91 [1.08-3.35]), premenstrual tension (1.67 [1.09-2.56]) or an early age at first pregnancy (1.45 [1.05-1.99]).Conclusions: Presence of both symptoms was associated with social, behavioural and menstrual factors. There were some differences in risk factors among women who reported only one or both symptoms, suggesting a slightly different aetiology for each.

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