Details of Publication 598 for Project A231A:

Chiarelli P & Sibbritt D. Osteoporosis and pelvic organ prolapse in Australian women: A longitudinal analysis. , 2012; : 151-152

Objective: This study aimed to longitudinally explore associations between diagnosis of osteoporosis in relation to self reported pelvic organ prolapse surgery in Australian women. Background: In women, urinary incontinence, pelvic organ prolapse and osteoporosis are prevalent, progressive disorders. Osteoporosis is characterised by compromised bone strength resulting in vertebral fractures, the most prevalent female osteoporotic fractures. Such fractures are strongly correlated with spinal deformity, and height loss hypothesised to increase intraabdominal pressure. Height loss inherent with osteoporosis is significantly associated with female urinary incontinence [1] which is also significantly associated with pelvic organ prolapse Methods: In the first survey (1996), women were asked if they had “ever been told by a doctor that you had osteoporosis”. In subsequent surveys were asked “in the last 2 years have you been diagnosed or treated for osteoporosis”. Mid aged women were asked if they had repair of prolapse of the uterus, bladder or bowel in the previous three years in each survey while women in the ‘older’ group were asked in each if they had ever been told by a doctor they had POP in the first three surveys only. Responses were analysed from 10,951 mid-aged women (aged 45-50 years in 1966) across 5 surveys and 8847 elderly women (aged 70–75 in 1996) across 4 surveys in the Australian Longitudinal Study on Women's Health. After adjusting for confounders, crude and adjusted odds ratios for osteoporosis were obtained using longitudinal generalized estimating equation models, predicting pelvic organ prolapsed for both cohorts. Results: Statistically significant associations were found between osteoporosis and self-reported surgery for pelvic organ prolapse (OR=1.46; 95% CI: 1.13, 1.89) in mid-age women and being told by a doctor they have POP in older women (OR = 1.44 (CI:1.27, 1.64).Conclusion: Mid-aged and older women diagnosed with osteoporosis are at increased risk of developing pelvic organ prolapse suggesting that on diagnosis of osteoporosis, women be screened for and informed about their increased risk of developing pelvic organ prolapse.

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