Details of Publication 599 for Project A231A:

Chiarelli P & Sibbritt D. Osteoporosis and urinary incontinence in Australian women: A longitudinal analysis. , 2012; : 768-769

Hypothesis / aims of study: In women, urinary incontinence and osteoporosis are prevalent, progressive disorders. Osteoporosis is characterised by compromised bone strength resulting in vertebral fractures, the most prevalent female osteoporotic fractures. Such fractures are strongly correlated with spinal deformity, and height loss - hypothesised to increase intraabdominal pressure. Height loss inherent with osteoporosis is significantly associated with female urinary incontinence which is associated with pelvic organ prolapse [1]. This study aimed to longitudinally explore associations between diagnoses of osteoporosis in relation to onset of urinary incontinence in Australian women. Study design, materials and methods: In the first survey (1996), women were asked if they had “ever been told by a doctor that you had osteoporosis”. In subsequent surveys were asked “in the last 2 years have you been diagnosed or treated for osteoporosis”. Other baseline survey questions in both cohorts asked whether women had experienced leaking urine in the last year. Response options were: never, rarely, sometimes, or often. Responses to this question (those answering rarely, sometimes, often) were used to estimate the prevalence of leaking urine in both cohorts in each survey. Responses were analysed from 10,951 mid-aged women (aged 45-50 years in 1966) and 8847 elderly women (aged 70–75 in 1996) across 5 surveys in the Australian Longitudinal Study on Women's Health. After adjusting for confounders, crude and adjusted odds ratios for osteoporosis were obtained using longitudinal generalized estimating equation models, predicting incontinence for both cohorts.Results: Statistically significant associations were found between osteoporosis and urinary incontinence (OR=1.21; 95% CI: 1.11, 1.33) in both the mid-age and older women.Conclusion: Mid-aged and older women diagnosed with osteoporosis are at increased risk of developing urinary incontinence suggesting that on diagnosis of osteoporosis, women be screened for and informed about their increased risk of developing urinary incontinence .