Details of Publication 724 for Project A240C:

Joham A, Boyle J, Ranasinha S, Zoungas S & Teede H. Contraception use and pregnancy outcomes in women with polycystic ovary syndrome: Data from the Australian Longitudinal Study on Women's Health. Human Reproduction, 2014; 29(4): 802-808

Study question: Do contraception use, pregnancy outcome and number of children differ in women with and without polycystic ovary syndrome (PCOS)?Summary answer: Women with PCOS were less likely to report use of contraception and more likely to report a miscarriage, whilst number of children was similar between groups.What is known already: The oral contraceptive pill is used in the management of PCOS, but the patterns of contraception use in women with PCOS is not known. In women with PCOS who undergo assisted reproduction, the risk of pregnancy loss appears higher, yet pregnancy loss and family size among community-based women with PCOS is not known.Study design, size and duration: This is a cross-sectional analysis of a longitudinal cohort study. Mailed survey data were collected at five time points (years 1996, 2000, 2003, 2006 and 2009). Data from respondents to Survey 4 (2006), aged 28–33 (n = 9145, 62% of the original cohort aged 18–23 years) were analysed.Participants/materials, settings, methods: This study was conducted in a general community setting. Data from participants who responded to the questions on PCOS, contraception and pregnancy outcome were analysed. The main outcome measures were self-reported PCOS, body mass index (BMI), contraception use, pregnancy loss and number of children.Main results and the role of chance: In women aged 28–33 years, women with PCOS were less likely to be using contraception (61 versus 79%, P < 0.001) and more likely to be trying to conceive (56 versus 45%, P < 0.001), compared with women not reporting PCOS. A greater proportion of women with PCOS reported pregnancy loss (20 versus 15%, P = 0.003). PCOS was not independently associated with pregnancy loss; however, BMI was independently associated with pregnancy loss in the overweight and obese groups (OR 1.2, 95% CI 1.04–1.4, P = 0.02 and OR 1.4, 95% CI 1.1–1.6, P = 0.001, respectively). Fertility treatment use was also independently associated with pregnancy loss (adjusted OR 3.2, 95% CI 2.4–4.2, P < 0.001). There was no significant difference in number of children between women with and without PCOS.Limitations, reason for caution: PCOS, contraception use and pregnancy outcome data were self-reported. Attrition occurred, but is reasonable compared with similar longitudinal cohort studies.Wider implications of the findings: This community-based cohort aged 28–33 years provides insights into the contraceptive use, pregnancy loss and family size of a large cohort of unselected women. Women reporting PCOS had lower rates of contraception use and were more likely to be currently trying to conceive, suggesting that they may be aware of potential fertility challenges, yet in those not planning to conceive, contraceptive use was low and further education may be required. Despite prior reports of higher rates of pregnancy loss in PCOS, usually from infertility services, in this community-based population, PCOS was not independently associated with pregnancy loss, yet independent risk factors for pregnancy loss included higher BMI, were higher in PCOS. The number of children per woman was similar in the both groups, albeit with more infertility treatment in PCOS. This may reassure women with PCOS that with access to fertility treatment, family sizes appear similar to women not reporting PCOS.Study findings/competing interest: This epidemiological research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors. A.E.J. is an NHMRC postgraduate scholarship holder, H.J.T. and J.A.B. are NHMRC postdoctoral research fellows and S.Z. is a NHF postdoctoral research fellow. The ALSWH is funded by the Australian Government Department of Health and Ageing. The authors declare that there is no conflict of interest associated with this manuscript.

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